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KMID : 0355220070320010035
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Journal of Korean Academy Oral Medicine
2007 Volume.32 No. 1 p.35 ~ p.43
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The Effect of Herbal Formulation (OPB), Rehmannia Glutinosa Libosch and Eleutherococcus Senticosus Max Extracts on Bone Density and Bone Biochemical Marker in Ovariectomized Rats
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Kim Jung-Keun
Kim Se-Won
Lee Byung-Eui
Hwang Hyeon-Hwan
Kwon Jong-Seok
Ko Seon-Yle
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Abstract
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This study was conducted to investigate the preventing effects of OPB (water extracts of Rehmannia glutinosa Libosch and Eleutherococcus senticosus Max) on bone loss in ovariectomized rats. Twenty Sprague Dawley rats of 13 week-old were divided into two groups: control group (ovariectomized, OVX)) and experimental group (OVX + OPB). The preventing effects of OPB on bone loss, OPB were fed with 100 ㎎ OPB/㎏ body weight from 3 days after ovariectomization. The duration of the treatment period was 8 weeks. All bone mineral density, bone mineral content indices and bone strength indices measured by peripheral quantitative computerized tomography (pQCT) and serum bone marker assessment were carried out at end of experiment. pQCT scanning showed that OVX induced a significant decrease in cancellous bone mineral density in the proximal tibia (-29.8 ± 3.0%). These decreases were significantly prevented by the administration of OPB 100 ㎎/㎏ (-21.4±2.3%. p＜0.05). Bone strength indices showed significant difference between OVX and OPB treated rats (anti-fracture, anti-twisting, p＜0.05). These data suggested that administration of OPB inhibited the loss of bone in OVX rats. CTx level were lower than in the OPB-treated animals compared with OVX. However there was no significant difference between OVX and OPB treated OVX rat. Our results suggest that OPB is effective in preventing the development of bone loss induced by ovariectomy in rats.
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KEYWORD
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Bone mineral density, CTx(C-telopeptide of type Ⅰ collagen), Eleutherococcus senticosus Max, Osteoporosis, Rehmannia glutinosa Libosch
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